IP-6:
THE REVOLUTIONARY CANCER FIGHTER

Dr. AbulKalam M. Shamsuddin MD, PhD., describes in his book, "IP-6: Nature's Revolutionary Cancer Fighter", the amazing results of his ground-breaking experiments of the last 15 years, as to how the B-vitamin inositol and its derivative inositol hexaphosphate (IP-6) prevent the formation of cancer and even shrink pre-existing experimental cancers. He also describes the many other fascinating health benefits of these natural products. IP-6 and Inositol boost the immune system, help lower cholesterol, prevent kidney stones and the complications of diabetes and sickle cell anemia, and reduce the risk of cardiovascular diseases, including heart attack and stroke.

THE AUTHOR

Dr. AbulKalam M. Shamsuddin MD, PhD, is Professor of Pathology at the University of Maryland School of Medicine in Baltimore. Since 1975, he has been researching the processes of cancer formation, cancer prevention and cancer treatment. Inventor of a rapid, simple and inexpensive screening test for colorectal cancer, he is also the pioneering scientist who demonstrated the immune-enhancing and anti-cancer actions of IP-6 & Inositol, for which he was awarded the US patent #5,082,833.

THE SCIENCE

First performed in Dr. Shamsuddin's laboratory, experiments on the anti-cancer action of IP-6 and Inositol have been subsequently reproduced and extended by scientists around the world, reconfirming these fascinating findings. Inositol and IP-6, and the other inositol phosphates i.e. IP-1, IP-2, IP-3, IP-4, IP-5 are normally present in all mammalian cells.

IP-3 is a key molecule responsible for cellular signal transduction, controlling vital functions including cell proliferation and differentiation. IP-6 can lose one or more phosphate (P) while inositol can gain them. Thus the combination of IP-6 and Inositol could yield more of the crucial IP-3.

The theory is, since:

  1. all cancers, irrespective of their type and origin have a common defect of uncontrolled cell proliferation,

  2. IP-3 is a key regulator of cell growth, and

  3. IP-6 & Inositol yield IP-3.
Therefore, IP-6 and Inositol should be effective against many different types of cancers, and across species.


IP-6 SYMPOSIUM PROCEEDINGS

The First International Symposium on Disease Prevention by IP-6 and Other Rice Components was held in Kyoto, Japan [June 8-9, 1998]. More than 30 experts from around the world presented their results to an audience of over 550 physicians, scientists, nutritionists, and other health care professionals.

Besides the anti-cancer actions of IP-6 and inositol against a variety of cancer models, other potential health benefits as well as the scientific mechanism of action of these natural compounds extracted from rice were discussed.
As an example:
  • Dr. Raxit Jariwalla from the California Institute for Medical Research in San Jose, showed that IP-6 can lower serum lipid level and prevent atherosclerosis;

  • Dr. Tetsuyuki Katayama of Hiroshima University presented data showing that IP-6 and inositol can prevent fatty liver formation, an early step in the pathogenesis of cirrhosis of the liver;

  • Professor Felix Grases from the University of Balearic Islands demonstrated that IP-6 prevented kidney stone formation;

  • Dr. Ivana Vucenik from the University of Maryland reported that IP-6 can inhibit aggregation of platelets, a crucial step in atherosclerosis;

  • Professor Per-Olof Berggren from the Karolinska Institute in Stockholm, presented the results of his experiments showing how IP-6 itself can act as a regulator of insulin secretion;

  • Professor George Weber from Indiana University reviewed how IP-3 could be crucial in cancer cells' ability to proliferate and how IP-6 could play a role in maintaining IP-3 concentration in a homeostatic adaptation, and

  • Professor Lucio Cocco from University of Bologna discussed how nuclear inositol lipids are important in switching cell programming from a proliferative to a differentiative state.

Papers from these and other experts have recently been published as meeting proceedings in a special issue of the journal ANTICANCER RESEARCH (volume 19 Number 5A, 1999).


IP-6 IN COLON CANCER MODEL

The 9th Annual Research Conference of the American Institute for Cancer Research was held in Washington, D.C., on September 2-3, 1999. Researchers - April Carney, Nancy Turner, and Robert Chapkin from Dr. Joanne Lupton's laboratory at Texas A & M University at College Station, reported that IP-6 can reduce the number and multiplicity of ACF [Aberrant Crypt Foci - precancerous lesions in the colon] in rats challenged with the carcinogen, azoxymethane. The highest dose level (1.2 g IP-6/kg of diet) produced the fewest ACFs and statistically, the reductions were highly significant [p<0.0001 and p<0.0004]. This report provides additional experimental support for the role of IP-6 in the prevention of colon cancer [Reference - Poster Abstract Booklet].


INOSITOL AND LUNG CANCER PREVENTION

Dr. Stephen S. Hecht and his colleagues at the University of Minnesota Cancer Center, American Health Foundation in New York and University of Toronto, reported in the April 1, 1999 issue of the journal CANCER LETTERS [vol. 137 pages 123-130, 1999] on the results of their experiment on lung cancer prevention. Using a mouse model of chemically induced lung tumors, these scientists tested the efficacy of BHA - a common food additive, curcumin - the yellow pigment of turmeric, esculetin, resveratrol of red wine, lycopene from tomato and inositol in cancer prevention. Their results show a 60% reduction in the number of lung tumors by inositol (25 tumor/mouse in control to 10 in inositol treatment group). The authors conclude "among the compounds tested, myo-inositol is most effective after carcinogen treatment."


IP-6 AGAINST PROSTATE CANCER

Drs. X. Zi and R. Agarwal of AMC Cancer Research Center, Denver CO, reported at the 90th Annual Meeting of the American Association for Cancer Research in Philadelphia, PA [April 10-14, 1999, Abstract #4312] that IP-6 reproducibly inhibited the growth of human prostate cancer cells in the laboratory. These investigators used PCA DU145 cell line; a previous study by Shamsuddin & Yang [CARCINOGENESIS vol 16: 1975-1979, 1995] demonstrated the effectiveness of IP-6 against another human prostate cancer cell line PC-3.


IP-6 AND MRNA TRANSPORT

Transcription of DNA to messenger RNA (mRNA) in eukaryotic cells is performed in the nucleus, and the mRNA is exported from the nucleus to the cytoplasm. Dr. John D. York and his collaborators from Duke University Medical Center in Durham and Washington University School of Medicine in St. Louis, report in 2 July 1999 issue of the journal SCIENCE [Vol. 285, pages 96-100] that the generation of IP-6 is required for proper and efficient nuclear export of mRNA to the cytoplasm. This study indicates that such export of mRNA may be in response to signaling mediated by IP-6. Thus increased intracellular IP-6 may enhance nuclear export of mRNA. "..these studies constitute a signaling pathway from phosphatidylinositol 4,5 bisphosphate to inositol hexakisphosphate (IP6)."



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Updated January 01, 2007

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*Under current legislation, The Wolfe Clinic is not permitted to make claims to consumers in support of health benefits derived from foods. This means we cannot make specific statements as to how food-based, non-drug products may help to prevent or treat diseases or our government will attempt to re-classify that food as a drug. Taking natural products should be a decision based on personal research and understanding of the role food-derived antioxidants and enzymes play in health and wellbeing.

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